RED NUCLEUS;
L-ARGININE;
ANALGESIA;
NITRIC OXIDE (NO);
CGMP;
D O I:
10.1016/0014-2999(95)00105-T
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
There is considerable evidence that nitric oxide (NO) plays a role in synaptic transmission in both central and peripheral nervous systems. Recent studies have suggested the involvement of the L-arginine NO pathway in nociceptive transmission/modulation. Electrical stimulation of the red nucleus in the rat evokes potent analgesia. Microinjection of different concentrations of L-arginine (1 nmol-1 mu mol), but not of D-arginine, produced quick and long-lasting analgesia. Pretreatment with N-nitro-L-arginine methyl ester (1 mu mol), a nitric oxide synthase inhibitor, significantly prevented L-arginine-induced analgesia. Further, pretreatment of animals with methylene blue, a known guanylate cyclase inhibitor, also attenuated the development of analgesia. Our results suggest that L-arginine caused production of NO, which in turn activated the red nucleus analgesic system.
机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL
DUARTE, IDG
LORENZETTI, BB
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机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL
LORENZETTI, BB
FERREIRA, SH
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL
机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL
DUARTE, IDG
LORENZETTI, BB
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL
LORENZETTI, BB
FERREIRA, SH
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZILUNIV SAO PAULO, FAC MED RIBEIRAO PRETO, DEPT PHARMACOL, BR-14049 RIBEIRAO PRETO, BRAZIL