POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN RED NUCLEUS STIMULATION-INDUCED ANALGESIA IN THE RAT

被引:17
作者
KUMAR, A
RAGHUBIR, R
DHAWAN, BN
机构
[1] Division of Pharmacology, Central Drug Research Institute, Lucknow
关键词
RED NUCLEUS; L-ARGININE; ANALGESIA; NITRIC OXIDE (NO); CGMP;
D O I
10.1016/0014-2999(95)00105-T
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
There is considerable evidence that nitric oxide (NO) plays a role in synaptic transmission in both central and peripheral nervous systems. Recent studies have suggested the involvement of the L-arginine NO pathway in nociceptive transmission/modulation. Electrical stimulation of the red nucleus in the rat evokes potent analgesia. Microinjection of different concentrations of L-arginine (1 nmol-1 mu mol), but not of D-arginine, produced quick and long-lasting analgesia. Pretreatment with N-nitro-L-arginine methyl ester (1 mu mol), a nitric oxide synthase inhibitor, significantly prevented L-arginine-induced analgesia. Further, pretreatment of animals with methylene blue, a known guanylate cyclase inhibitor, also attenuated the development of analgesia. Our results suggest that L-arginine caused production of NO, which in turn activated the red nucleus analgesic system.
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页码:1 / 5
页数:5
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