SYNTHESIS OF OCTACARBOXYTETRA(2,3-PYRAZINO)PORPHYRAZINE - NOVEL WATER-SOLUBLE PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY

被引：47

作者：

KUDREVICH, SV

GALPERN, MG

VANLIER, JE

机构：

[1] UNIV SHERBROOKE,FAC MED,MRC,RADIAT SCI GRP,SHERBROOKE J1H 5N4,PQ,CANADA

[2] MOSCOW ORGAN INTERMED & DYE RES INST,MOSCOW 103787,RUSSIA

来源：

SYNTHESIS-STUTTGART | 1994年 / 08期

关键词：

PHTHALOCYANINE; AZA ANALOG; OCTACARBOXY DERIVATIVE; PHOTODYNAMIC THERAPY;

D O I：

10.1055/s-1994-25571

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation of 2,3-dicyano-5,6-diethoxycarbonylpyrazine with a metal salt affords tetra-2,3-(5,6-diethoxycarbonylpyrazino)porphyrazine, which upon mild hydrolysis yields novel water-soluble metal complexes of tetra-2,3-(5,6-dicarboxypyrazino)porphyrazine. These octaaza analogs of phthalocyanine have potential applications in the field of photodynamic therapy of cancer.

引用

页码：779 / 781

页数：3

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