A muscarinic ganglionic stimulant, 4-(m-chlorophenyl-carbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) administered into the perfused canine caudal vesical arteries caused a contraction of the bladder resembling that elicited by acetyylcholine. The contraction produced by McN-A-343 was abolished by tetrodotoxin as that induced by a nicotinic ganglionic stimulant, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). However, unlike the response to DMPP, the response to McN-A-343 was abolished by atropine as readily as that to acetylcholine. These results indicate that the parasympathetic ganglia in the bladder wall have muscarinic sites distinct from those activated by nicotinic compounds as do sympathetic ganglia elsewhere. © 1968, Tohoku University Medical Press. All rights reserved.
