CAPACITY OF THE MUCOSAL TRANSFER SYSTEM AND ABSORPTION OF IRON AFTER ORAL-ADMINISTRATION IN RATS

被引:19
作者
BECKER, G [1 ]
KORPILLASCHAFER, S [1 ]
OSTERLOH, K [1 ]
FORTH, W [1 ]
机构
[1] RUHR UNIV BOCHUM,INST PHARMAKOL & TOKIKOL,D-4630 BOCHUM,FED REP GER
来源
BLUT | 1979年 / 38卷 / 02期
关键词
Gastric emptying time and iron absorption; Iron absorption; Iron retention; Saturation type curve of iron absorption;
D O I
10.1007/BF01007953
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1. The dose dependence of the iron absorption shows a saturation characteristic if iron (0.25-5 μmoles Fe/kg body weight) is administered in tied-off intestinal segments of normal and iron-deficient rats. 2. If the iron doses (2.1-570 μmoles Fe/kg body weight) are administered by stomach tube only in normal rats a similar dose dependence curve has been obtained as after administration in tied-off intestinal segments. In irondeficient rats the shape of the dose dependence curve is changed and shows no clear-cut saturation characteristic. 3. The differences of these dose dependence curves are discussed with respect to the differences of the methodological conditions. A saturation type kinetic for absorption cannot be expected under all experimental condititions despite of the existence of a transfer system with limited capacity for the transport of iron. © 1979 Springer-Verlag.
引用
收藏
页码:127 / 134
页数:8
相关论文
共 20 条
[1]   STUDIES IN IRON METABOLISM .4. IRON ABSORPTION IN EXPERIMENTAL IRON DEFICIENCY [J].
BANNERMAN, RM ;
WITTS, LJ ;
OBRIEN, JRP .
BLOOD, 1962, 20 (05) :532-&
[2]   EFFECT OF ACUTE HAEMORRHAGE AND ACUTE HAEMOLYSIS ON INTESTINAL IRON ABSORPTION IN RAT [J].
CHIRASIRI, L ;
IZAK, G .
BRITISH JOURNAL OF HAEMATOLOGY, 1966, 12 (05) :611-+
[3]  
FORTH W, 1969, ARZNEI-FORSCHUNG, V19, P363
[4]   REGULATION OF IRON RESORPTION BY GASTROFERRIN AN IRON-BINDING PROTEIN FROM GASTRIC JUICE [J].
FORTH, W ;
RUMMEL, W .
KLINISCHE WOCHENSCHRIFT, 1968, 46 (18) :1003-+
[5]   IRON-ABSORPTION [J].
FORTH, W ;
RUMMEL, W .
PHYSIOLOGICAL REVIEWS, 1973, 53 (03) :724-792
[6]  
FORTH W, 1965, ARCH EXP PATHOL PH, V252, P242
[7]  
GABBE EE, 1975, IRON METABOLISM ITS, P278
[8]   KINETICS OF IRON ABSORPTION IN MICE [J].
GITLIN, D ;
CRUCHAUD, A .
JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (02) :344-&
[9]  
GORNALL AG, 1949, J BIOL CHEM, V177, P751
[10]   IRON METABOLISM IN HUMAN PREGNANCY AS STUDIED WITH THE RADIOACTIVE ISOTOPE FE-59 [J].
HAHN, PF ;
CAROTHERS, EL ;
DARBY, WJ ;
MARTIN, M ;
SHEPPARD, CW ;
CANNON, RO ;
BEAM, AS ;
DENSEN, PM ;
PETERSON, JC ;
MCCLELLAN, GS .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1951, 61 (03) :477-486