HIGH-DOSE STEROIDS IN ACUTE RELAPSES OF MULTIPLE-SCLEROSIS - MRI EVIDENCE FOR A POSSIBLE MECHANISM OF THERAPEUTIC EFFECT

被引：150

作者：

MILLER, DH ^{[1
]}

THOMPSON, AJ ^{[1
]}

MORRISSEY, SP ^{[1
]}

MACMANUS, DG ^{[1
]}

MOORE, SG ^{[1
]}

KENDALL, BE ^{[1
]}

MOSELEY, IF ^{[1
]}

MCDONALD, WI ^{[1
]}

机构：

[1] UCL NATL HOSP NEUROL & NEUROSURG, LONDON WC1N 3BG, ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1992年 / 55卷 / 06期

关键词：

D O I：

10.1136/jnnp.55.6.450

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The integrity of the blood-brain barrier (BBB) in multiple sclerosis (MS) was monitored by serial gadolinium-(Gd)-DTPA enhanced MRI during and after the treatment of acute relapses with a three day course of high dose intravenous methylprednisolone (IVMP). During treatment there was a rapid reduction of BBB abnormalities in 96% of enhancing lesions. In spite of sustained clinical improvement, many lesions re-enhanced within a few days of stopping IVMP, and new lesions frequently appeared within one month. It is possible that the rapid, albeit transient, reversal of BBB abnormalities contributes to the accelerated recovery from relapses associated with IVMP treatment.

引用

页码：450 / 453

页数：4

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