SURPRISING REACTIVITY OF (METHYL 2-ACETAMIDOACRYLATE)TRICARBONYLIRON(0) LEADING TO THE SYNTHESIS OF BETA,BETA,BETA-TRIALKYL ALPHA-AMINO-ACIDS

被引：10

作者：

BARKER, J

COOK, SL

LASTERRASANCHEZ, ME

THOMAS, SE

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] ASSOCIATED OCTEL CO LTD,WIRRAL L65 4HF,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 11期

关键词：

D O I：

10.1039/c39920000830

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Addition of methyllithium followed by tertiary haloalkanes to readily available and air-stable (methyl 2-acetamidoacrylate)tricarbonyliron(0) 1, gives protected beta,beta,beta-trialkyl alpha-amino acids which are hydrolysed to give tert-leucine 10 and the new alpha-amino acids 2-amino-3,3-dimethylpentanoic acid 11 and 2-amino-3,3-dimethylhexanoic acid 12.

引用

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页码：830 / 832

页数：3

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