DIFFERENTIAL EFFECT OF TRANSFORMING GROWTH-FACTOR-BETA ON THE SYNTHESIS OF T(H)1-LYMPHOKINES AND T(H)2-LIKE LYMPHOKINES BY HUMAN LYMPHOCYTES-T

被引：123

作者：

FARGEAS, C

WU, CY

NAKAJIMA, T

COX, D

NUTMAN, T

DELESPESSE, G

机构：

[1] UNIV MONTREAL, NOTRE DAME HOSP, ALLERGY RES LAB, 1560 SHERBROOKE ST E, MONTREAL H2L 4M1, QUEBEC, CANADA

[2] NIAID, PARASIT DIS LAB, BETHESDA, MD 20892 USA

[3] CIBA GEIGY PHARMACEUT CORP, BASEL, SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 08期

关键词：

D O I：

10.1002/eji.1830220833

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

(TGF)-beta is a pluripotent cytokine exerting differential effects on distinct components of the immune response. The present report, based on lymphokine determination in culture supernatants and Northern blot analysis of lympokine mRNA, demonstrates that TGF-beta-2 markedly inhibits interleukin (IL)-4 and IL-5 synthesis by polyclonally activated human T cells in the absence of any significant effect on (IFN)-gamma, lymphotoxin or IL-2, suggesting a modulatory effect of TGF-beta-2 on the interferon T(h)1/T(h)2) balance of immune responses. The inhibitory effect of TGF-beta on IFN-gamma production by unfractionated peripheral blood mononuclear cells is likely to reflect the blunting of natural killer cell activation by TGF-beta.

引用

收藏

页码：2173 / 2176

页数：4

相关论文

共 37 条

[1] REGULATION OF TRANSFORMING GROWTH FACTOR-BETA-1 GENE-EXPRESSION BY GLUCOCORTICOIDS IN NORMAL HUMAN LYMPHOCYTES-T [J].

AYANLARBATUMAN, O ;

FERRERO, AP ;

DIAZ, A ;

JIMENEZ, SA .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) :1574-1580

[2] CROSS-LINKING FC-RECEPTORS STIMULATE SPLENIC NON-B, NON-T CELLS TO SECRETE INTERLEUKIN-4 AND OTHER LYMPHOKINES [J].

BENSASSON, SZ ;

LEGROS, G ;

CONRAD, DH ;

FINKELMAN, FD ;

PAUL, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1421-1425

[3]

BENSASSON SZ, 1990, J IMMUNOL, V145, P1127

[4] DIFFERENTIAL REGULATION OF INTERLEUKIN-4 AND INTERLEUKIN-5 GENE-EXPRESSION - A COMPARISON OF T-CELL GENE INDUCTION BY ANTI-CD3 ANTIBODY OR BY EXOGENOUS LYMPHOKINES [J].

BOHJANEN, PR ;

OKAJIMA, M ;

HODES, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5283-5287

[5]

BROIDE DH, 1989, J IMMUNOL, V143, P1591

[6] TRANSFORMING GROWTH FACTOR-BETA SPECIFICALLY ENHANCES IGA PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED MURINE LYMPHOCYTES-B [J].

COFFMAN, RL ;

LEBMAN, DA ;

SHRADER, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) :1039-1044

[7]

COX DA, 1991, EUR J BIOCHEM, V188, P467

[8] TRANSFORMING GROWTH-FACTOR-BETA IS A POTENT INHIBITOR OF INTERLEUKIN-1 (IL-1) RECEPTOR EXPRESSION - PROPOSED MECHANISM OF INHIBITION OF IL-1 ACTION [J].

DUBOIS, CM ;

RUSCETTI, FW ;

PALASZYNSKI, EW ;

FALK, LA ;

OPPENHEIM, JJ ;

KELLER, JR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) :737-744

[9] INHIBITION OF CYTOKINE PRODUCTION BY CYCLOSPORINE-A AND TRANSFORMING GROWTH-FACTOR-BETA [J].

ESPEVIK, T ;

FIGARI, IS ;

SHALABY, MR ;

LACKIDES, GA ;

LEWIS, GD ;

SHEPARD, HM ;

PALLADINO, MA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (02) :571-576

[10] LYMPHOKINE CONTROL OF INVIVO IMMUNOGLOBULIN ISOTYPE SELECTION [J].

FINKELMAN, FD ;

HOLMES, J ;

KATONA, IM ;

URBAN, JF ;

BECKMANN, MP ;

PARK, LS ;

SCHOOLEY, KA ;

COFFMAN, RL ;

MOSMANN, TR ;

PAUL, WE .

ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :303-333

← 1 2 3 4 →