STRESS-INDUCED MODULATION OF THE IMMUNE-RESPONSE TO RECOMBINANT HEPATITIS-B VACCINE

被引:242
作者
GLASER, R
KIECOLTGLASER, JK
BONNEAU, RH
MALARKEY, W
KENNEDY, S
HUGHES, J
机构
[1] OHIO STATE UNIV, COLL MED, DEPT PSYCHIAT, CTR COMPREHENS CANC, COLUMBUS, OH 43210 USA
[2] OHIO STATE UNIV, COLL MED, DEPT INTERNAL MED, COLUMBUS, OH 43210 USA
来源
PSYCHOSOMATIC MEDICINE | 1992年 / 54卷 / 01期
关键词
D O I
10.1097/00006842-199201000-00005
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Each of a series of three hepatitis B (Hep B) inoculations was given to 48 second-year medical students on the 3rd day of a 3-day examination series to study the effect of academic stress on the ability to generate an immune response to a primary antigen. Those students who seroconverted after the first injection (25%) were significantly less stressed and anxious than those who did not seroconvert at that time. In addition, students who reported greater social support demonstrated a stronger immune response to the vaccine at the time of the third inoculation, as measured by antibody titers to Hep B surface antigen (HBsAg) and the blastogenic response to a HBsAg peptide (SAg).
引用
收藏
页码:22 / 29
页数:8
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