SIDE-CHAIN ALTERED METHOTREXATE ANALOGS DESIGNED FOR IMPROVED MEMBRANE TRANSPORT

被引：15

作者：

CHAYKOVSKY, M

ROSOWSKY, A

MODEST, EJ

机构：

[1] CHILDRENS CANC RES FDN, BOSTON, MA 02115 USA

[2] HARVARD UNIV, MED SCH, DEPT BIOL CHEM, BOSTON, MA 02115 USA

[3] HARVARD UNIV, MED SCH, DEPT PATHOL, BOSTON, MA 02115 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1973年 / 10卷 / 03期

关键词：

D O I：

10.1002/jhet.5570100333

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：425 / 426

页数：2

共 12 条

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[2] POTENTIAL FOLIC ACID ANTAGONISTS .4. SYNTHETIC APPROACHES TO ANALOGS OF AMINOPTERIN AND METHOTREXATE .4. PREPARATION OF PARA-([(2,4-DIAMINO-6-PTERIDINYL)METHYL]AMINO)-BENZOIC ACIDS [J].

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[3]

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[4]

HITCHINGS GH, 1965, ADV ENZYMOLOGY, V27

[5] IMPROVED SYNTHESIS OF HOMOPTEROIC AND HOMOFOLIC ACIDS [J].

KIM, YH ;

FRIEDMAN, OM ;

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1972, 9 (03) :481-+

[6]

LIVINGSTON RB, 1970, SINGLE AGENTS CANCER

[7] BISHOMOFOLIC ACID . A NEW SYNTHESIS OF FOLIC ACID ANALOGS [J].

MOSHER, CW ;

ACTON, EM ;

CREWS, OP ;

GOODMAN, L .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (05) :1452-&

[8]

ROSOWSKY A, 1971, ANN NY ACAD SCI, V186, P258

[9] SYNTHESES OF SOME ANALOGS OF A POSSIBLE INTERMEDIATE FORMED IN THYMIDYLATE SYNTHETASE REACTION [J].

SANTI, DV .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (04) :475-&

[10] ANALOGS OF PTEROYLGLUTAMIC ACID .3. 4-AMINO DERIVATIVES [J].

SEEGER, DR ;

COSULICH, DB ;

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HULTQUIST, ME .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (05) :1753-1758

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