BIS-NAPHTHALIMIDES .2. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5,6-ACENAPHTHALIMIDOALKYL-1,8-NAPHTHALIMIDOALKYL AMINES

被引：63

作者：

BRANA, MF ^{[1
]}

CASTELLANO, JM ^{[1
]}

MORAN, M ^{[1
]}

DEVEGA, MJP ^{[1
]}

QIAN, XD ^{[1
]}

ROMERDAHL, CA ^{[1
]}

KEILHAUER, G ^{[1
]}

机构：

[1] BASF AG,WORCESTER,MA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 03期

关键词：

BIS-INTERCALATOR; BIS-NAPHTHALIMIDE; CANCER; NAPHTHALIMIDE;

D O I：

10.1016/0223-5234(96)88230-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enhances aqueous solubility, we found that these compounds were no more soluble or cytotoxic than the homologous symmetric series.

引用

页码：235 / 239

页数：5

共 12 条

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