MODE OF DNA-BINDING OF BIS-BENZIMIDAZOLES AND RELATED STRUCTURES STUDIED BY ELECTRIC LINEAR DICHROISM

被引：19

作者：

BAILLY, C

COLSON, P

HOUSSIER, C

WANG, HY

BATHINI, Y

LOWN, JW

机构：

[1] INST RECH CANC, INSERM, U124, F-59045 LILLE, FRANCE

[2] UNIV LIEGE, CHIM MACROMOLEC & CHIM PHYS LAB, B-4000 LIEGE, BELGIUM

[3] UNIV ALBERTA, DEPT CHEM, EDMONTON T6G 2G2, AB, CANADA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1994年 / 12卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1080/07391102.1994.10508095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The binding mode of a series of bis-benzimidazole analogues of Hoechst 33258 to a variety of DNAs and polynucleotides has been investigated by electric linear dichroism. Two groups of compounds were examined: (i) benzoxazole and pyridoimidazole derivatives and (ii) pyridoimidazole analogs substituted with an N-alkoxyalkyl group either directed towards the minor groove or directed away from the minor groove. The ELD data indicate that the mode of binding of these drugs varies significantly with the sequence of the target DNA sequence. The DNA binding properties' of these drugs are related to their topoisomerase inhibitory properties.

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页码：173 / 181

页数：9

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