PSYCHOTROPIC-DRUGS AS BEHAVIORAL TERATOGENS

被引：137

作者：

VORHEES, CV ^{[1
]}

BRUNNER, RL ^{[1
]}

BUTCHER, RE ^{[1
]}

机构：

[1] UNIV CINCINNATI,COLL MED,CINCINNATI,OH 45221

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.472738

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means. Copyright © 1979 AAAS.

引用

页码：1220 / 1225

页数：6

共 39 条

[1]

Biel WC, 1940, PEDAGOG SEMIN J GEN, V56, P439

[2] LONG-TERM EFFECTS OF OBSTETRICAL-ANESTHESIA ON INFANT AUTONOMIC FUNCTION [J].