USE OF THE CALCIUM AGONIST BAY K-8644 FOR INVITRO DIAGNOSIS OF SUSCEPTIBILITY TO MALIGNANT HYPERTHERMIA

被引：5

作者：

ADNET, PJ

KRIVOSICHORBER, RM

HAUDECOEUR, G

ADAMANTIDIS, MM

REYFORD, GH

IMBENOTTE, M

CORDONNIER, C

机构：

[1] CHU LILLE,PHARMACOL HOSP LAB,F-59037 LILLE,FRANCE

[2] CHU LILLE,FAC PHARM,F-59037 LILLE,FRANCE

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 65卷 / 06期

关键词：

Hyperthermia:; malignant; in vitro test; Pharmacology: calcium channel blocker; BAY K 8644;

D O I：

10.1093/bja/65.6.791

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups. © 1990 Copyright: 1990 British Journal of Anaesthesia.

引用

页码：791 / 795

页数：5

共 16 条

[1] COMPARISON OF THE CAFFEINE SKINNED FIBER TENSION (CSFT) TEST WITH THE CAFFEINE-HALOTHANE CONTRACTURE (CHC) TEST IN THE DIAGNOSIS OF MALIGNANT HYPERTHERMIA [J].