EXPERIMENTAL STUDIES OF CHRONIC PNEUMONIA OF SHEEP

被引:39
作者
GILMOUR, JS
JONES, GE
RAE, AG
机构
[1] Animal Diseases Research Association, Moredun Institute, Edinburgh, EH 17 7JH
关键词
chronic pneumonia; mycoplasmas; Pasteurellae; Sheep; SPF lambs;
D O I
10.1016/0147-9571(79)90030-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Strains of Mycoplasma ovipneumoniae and Pasteurella haemolytica isolated from sheep affected with chronic pneumonia were inoculated by endobronchial route to conventionally-reared and SPF (Specific Pathogen-Free) lambs. Changes resembling those of the naturally-occurring disease were produced in most lambs given the organisms in combination and in some given M. ovipneumoniae alone. Similar but less extensive changes were seen in SPF lambs and fewer animals were affected. Different strains of M. ovipneumoniae did not affect the extent of changes produced in SPF lambs. M. ovipneumoniae became established in the lungs of both types of sheep; P. haemolytica did so less readily. It was concluded that chronic pneumonia may be reproduced in conventional animals by combined inoculation of M. ovipneumoniae and P. haemolytica. Age and status of immunity to mycoplasmas may account for the different responses of conventional and SPF lambs. © 1979.
引用
收藏
页码:285 / 293
页数:9
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