NEW CLASS OF ANTI-TUMOR COMPOUNDS - 5'-NOR AND 5',6'-SECO DERIVATIVES OF VINBLASTINE-TYPE ALKALOIDS

被引：73

作者：

MANGENEY, P ^{[1
]}

ANDRIAMIALISOA, RZ ^{[1
]}

LANGLOIS, N ^{[1
]}

LANGLOIS, Y ^{[1
]}

POTIER, P ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91190 GIF SUR YVETTE,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 22期

关键词：

D O I：

10.1021/jo01336a006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction medium obtained after applying the modified Polonovski reaction to the Nb'-oxide of anhydrovinblastine (3) led mainly to seco C5'-C6' derivatives after treatment with various nucleophiles. In the presence of cyanide ion, a minor product formed by nucleophilic attack onto the conjugated immonium salt 7 was also isolated. On the other hand, 20'-deoxyleurosidine Nb'-oxide (20) led only to seco C5'-C6' derivatives. © 1979, American Chemical Society. All rights reserved.

引用

页码：3765 / 3768

页数：4

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