CLONING OF A SEROTONIN TRANSPORTER AFFECTED BY ANTIDEPRESSANTS

被引：522

作者：

HOFFMAN, BJ ^{[1
]}

MEZEY, E ^{[1
]}

BROWNSTEIN, MJ ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,SCH MED,DEPT ANAT 1,H-1085 BUDAPEST 8,HUNGARY

来源：

SCIENCE | 1991年 / 254卷 / 5031期

关键词：

D O I：

10.1126/science.1948036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.

引用

页码：579 / 580

页数：2

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