ADAPTIVE REGULATION OF HORMONE INTERACTION WITH RECEPTOR

Results of various studies suggest the existence of regulatory factors controlling the interaction of hormone with receptor and the postreceptor processes. Hence, the hormone effect is actualized through private and attending regulations. The first consists in the induction of specific effects of the hormone in target tissues. The attending regulation is realized as: 1) modulating regulation, acting on the state and number of cellular receptors, 2) metabolic regulation, acting via the other receptors on the cellular metabolism and changing in such a way the actualization of private regulation, 3) regulation of protein synthesis, acting on the synthesis of structure and enzyme proteins, participating in the actualization of private regulation. In physiologic meaning the modulating regulation consists in guaranteeing (to maintain the accordance between numbers of binding sites and acting signal molecules), homeostatic (to maintain the hormone balance through the alterations on the receptor level) and stress (to fascilitate the regulatory effects through changes on receptor or postreceptor levels) regulations.