REDUCED NATURAL-KILLER-CELL CYTOTOXICITY IN DEPRESSION BUT NOT IN SCHIZOPHRENIA

被引：50

作者：

CALDWELL, CL

IRWIN, M ^{[1
]}

LOHR, J

机构：

[1] SAN DIEGO VET AFFAIRS MED CTR, DEPT PSYCHIAT V116A, 3350 LA JOLLA VILLAGE DR, SAN DIEGO, CA 92161 USA

[2] UNIV CALIF SAN DIEGO, LA JOLLA, CA 92093 USA

来源：

BIOLOGICAL PSYCHIATRY | 1991年 / 30卷 / 11期

关键词：

D O I：

10.1016/0006-3223(91)90183-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A reduction of natural killer (NK) cell activity has been found in hospitalized patients with major depressive disorder. To examine whether a reduction of NK activity is found in other psychiatric patients or related to the nonspecific effects of hospitalization, NK cell cytotoxicity was compared in hospitalized depressed patients, schizophrenic inpatients, and two groups of controls separately age matched to each patient group. NK activity was significantly (p < 0.01) lower in depressed inpatients than control subjects. However, in the hospitalized schizophrenic patients values of natural cytotoxicity did not differ from controls. These findings suggest that reduced NK cytotoxicity in depression is independent of the effects of hospitalization.

引用

页码：1131 / 1138

页数：8

共 38 条

[1] QUANTIFICATION OF NATURAL CYTO-TOXICITY BY HUMAN-LYMPHOCYTE SUBPOPULATIONS ISOLATED BY DENSITY - HETEROGENEITY OF THE EFFECTOR-CELLS [J].