PHOSPHORYLATION-INDEPENDENT MODULATION OF L-TYPE CALCIUM CHANNELS BY MAGNESIUM-NUCLEOTIDE COMPLEXES

被引：117

作者：

OROURKE, B ^{[1
]}

BACKX, PH ^{[1
]}

MARBAN, E ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,DEPT MED,DIV CARDIOL,BALTIMORE,MD 21205

来源：

SCIENCE | 1992年 / 257卷 / 5067期

关键词：

D O I：

10.1126/science.1321495

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Free magnesium ions and magnesium-nucleotide complexes can exert opposite effects on many fundamental cellular processes. Although increases in the intracellular concentration of magnesium ions inhibit the L-type calcium current in heart cells, magnesium-adenosine triphosphate complexes (MgATP) would be expected to increase the current by promoting channel phosphorylation. Rapid increases in the intracellular concentration of MgATP induced by flash photolysis of caged magnesium or caged ATP resulted in enhanced calcium current. The increase in calcium current was not prevented by blocking phosphorylation, revealing a previously unrecognized direct regulatory action of the magnesium-nucleotide complex.

引用

页码：245 / 248

页数：4

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