PHOSPHOLIPIDS AND PROTEIN-KINASE-C IN ACETYLCHOLINE-DEPENDENT SIGNAL TRANSDUCTION IN ASCARIS-SUUM

被引:8
作者
AREVALO, J [1 ]
SAZ, HJ [1 ]
机构
[1] UNIV NOTRE DAME,DEPT BIOL SCI,NOTRE DAME,IN 46556
关键词
ASCARIS; ACETYLCHOLINE; PHOSPHOLIPID; PROTEIN KINASE-C; 2ND MESSENGER; SIGNAL TRANSDUCTION; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE;
D O I
10.1016/0166-6851(91)90111-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quantitatively, the major phospholipid in the muscle of the nematode Ascaris suum was found to be phosphatidylcholine (lecithin). Stimulation of Ascaris muscle with acetylcholine or the agonists carbachol and levamisole increased the levels of phosphorylcholine, 1,2-diacylglycerides and phosphatidic acid. Increased levels of these compounds, together with the demonstration of phospholipase C activity, suggest that phospholipid hydrolysis may be associated with the ACh response of the muscle via second messenger pathways. In other tissues, diacylglycerides and phosphatidic acid have been reported to regulate protein kinase C activity. Protein kinase C activity also was demonstrated in the muscle of Ascaris. For optimal activity the kinase was dependent upon Ca2+, unsaturated 1,2-diacylglyceride and phospholipid. All of the data are in accord with the possible involvement of a second messenger system being operative in the ACh-stimulated contraction of Ascaris muscle.
引用
收藏
页码:151 / 161
页数:11
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