IMMUNOGLOBULIN-A-INDUCED SHIFT OF EPSTEIN-BARR-VIRUS TISSUE TROPISM

被引：177

作者：

SIXBEY, JW

YAO, QY

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT VIROL, MEMPHIS, TN 38101 USA

[2] ST JUDE CHILDRENS RES HOSP, DEPT MOLEC BIOL, MEMPHIS, TN 38101 USA

来源：

SCIENCE | 1992年 / 255卷 / 5051期

关键词：

D O I：

10.1126/science.1312750

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increased immunoglobulin A (IgA) antibodies to the Epstein-Barr virus (EBV) appear months to years before the clinical onset of nasopharyngeal carcinoma and define populations at high risk for this EBV-associated epithelial cancer common in south China. In the human HT-29 epithelial cell line, polymeric IgA (pIgA) specific for EBV promoted infection of the otherwise refractory epithelial cells. When bound to pIgA, EBV entered epithelial cells through secretory component-mediated IgA transport but no longer infected B lymphocytes. Such an immune-induced shift in EBV tissue tropism provides a paradigm for endogenous spread of EBV in the immune host that predicts infectious sequelae of epithelium.

引用

页码：1578 / 1580

页数：3

共 45 条

[1]

ALI MY, 1967, UICC UNION INT CONTR, V1, P138

[2] INTRAPEPTIDE AUTOPHOSPHORYLATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR - REGULATION OF KINASE CATALYTIC FUNCTION BY RECEPTOR DIMERIZATION [J].