INFECTION OF MACAQUE MONKEYS WITH A CHIMERIC HUMAN AND SIMIAN IMMUNODEFICIENCY VIRUS

被引：74

作者：

SAKURAGI, S

SHIBATA, R

MUKAI, R

KOMATSU, T

FUKASAWA, M

SAKAI, H

SAKURAGI, JI

KAWAMURA, M

IBUKI, K

HAYAMI, M

ADACHI, A

机构：

[1] KYOTO UNIV,INST VIRUS RES,KYOTO 606,JAPAN

[2] NAGASAKI UNIV,INST TROP MED,NAGASAKI 852,JAPAN

[3] NATL INST HLTH,TSUKUBA PRIMATE CTR MED SCI,TSUKUBA 305,JAPAN

[4] NATL INST HLTH,DIV POXVIRUSES & SPECIAL PATHOGENS,MUSASHIMURAYAMA,TOKYO 19012,JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-11-2983

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu and env genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.

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页码：2983 / 2987

页数：5

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