RAPID SERODIAGNOSIS OF TYPHOID-FEVER BY DOT ENZYME-IMMUNOASSAY IN AN ENDEMIC AREA

被引:40
作者
CHOO, KE
OPPENHEIMER, SJ
ISMAIL, AB
ONG, KH
机构
[1] UNIV SAINS MALAYSIA,SCH MED SCI,DEPT PAEDIAT,KELANTAN,MALAYSIA
[2] UNIV SAINS MALAYSIA,SCH MED SCI,DEPT MICROBIOL,KELANTAN,MALAYSIA
[3] CHINESE UNIV HONG KONG,DEPT PAEDIAT,SHA TIN,HONG KONG
关键词
D O I
10.1093/clinids/19.1.172
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A dot enzyme immunoassay (EIA) using 50-kD outer-membrane proteins (OMPs) of Salmonella typhi was compared with the Widal test for the serodiagnosis of typhoid fever in 109 febrile children admitted to a hospital in an endemic area. In the culture-positive typhoid group, the initial dot EIA was positive in 40 of 42 cases and the initial Widal test was positive in 41. In the culture-negative clinical typhoid group, both the dot EIA and the Widal test were positive in 17 of 18 cases. In the nontyphoidal fever group, the dot EIA was negative in all of 49 cases and the Widal test was negative in 44. With culture used as the gold standard, the dot EIA is as sensitive as the Widal test (95% vs. 98%), has a similar high negative predictive value (96% vs. 98%), and is more specific (75% vs. 67%). In addition, the dot EIA offers the advantages of simplicity, speed, early diagnosis, economy, and flexibility (i.e., other diagnostic tests can be conducted simultaneously).
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收藏
页码:172 / 176
页数:5
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