A SENSITIVE HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC TECHNIQUE BY WHICH TO MEASURE DIDEMNIN-B IN BIOLOGICAL-FLUIDS

被引：8

作者：

HARTSHORN, JN ^{[1
]}

TONG, WP ^{[1
]}

STEWART, JA ^{[1
]}

MCCORMACK, JJ ^{[1
]}

机构：

[1] UNIV VERMONT,COLL MED,DEPT PHARMACOL,BURLINGTON,VT 05405

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1986年 / 9卷 / 07期

关键词：

BIOLOGICAL MATERIALS - Chromatographic Analysis - CHROMATOGRAPHIC ANALYSIS - Liquid;

D O I：

10.1080/01483918608076698

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Didemnin B, a cyclic depsipeptide isolated from a Caribbean tunicate, has been recently determined to be active against B16 melanoma, both in vitro and in vivo, P388 leukemia in vivo and L1210 in vitro. This agent also inhibits DNA, RNA and protein synthesis and possesses antiviral activity. Using an in vitro stem cell assay, both T. L. Jian et al and A. H. Rossof, et al have demonstrated Didemnin B to have significant antitumor activity against several human tumor types, including carcinoma of the kidney, lung, breast, and ovary, mesothelioma, sarcoma, and hairy cell leukemia.

引用

页码：1489 / 1501

页数：13

共 11 条

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