GAS CHROMATOGRAPHIC ASSAY FOR BENZYL ALCOHOL AND PHENYLETHYL ALCOHOL IN PHARMACEUTICAL FORMULATIONS

被引：6

作者：

LINDEMAN.CJ

ROSOLIA, A

机构：

[1] Merck Sharp & Dohme, Research Laboratories, West Point, Pennsylvania

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Benzyl alcohol—analysis in dosage forms; Cyclohexanol—internal standard; GLC—analysis; Phenylethyl alcohol—analysis in dosage forms;

D O I：

10.1002/jps.2600580127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A gas chromatographic method has been developed for the determination of benzyl alcohol and phenylethyl alcohol in pharmaceutical formulations. The method employs a column made of a silanized copolymer of ethylvinylbenzene‐divinylbenzene and uses cyclohexanol as the internal standard. The method is applicable to various formulations which contain either benzyl alcohol or phenylethyl alcohol or the combination. Each analysis requires 10 min. This method showed a relative standard deviation of ±0.85% for benzyl alcohol and ±1.41% for phenylethyl alcohol. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：118 / &