SYNTHESIS OF 2-C-14-LABELED 3H-1,4-BENZODIAZEPINES

被引：17

作者：

TEGYEY, Z

MAKSAY, G

OTVOS, L

机构：

[1] Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, H-1525

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 03期

关键词：

1,4‐benzodiazepines; carbon‐14; synthesis;

D O I：

10.1002/jlcr.2580160303

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2‐14C‐oxazepam (7) 2‐14C‐(+)‐ and ‐(‐)‐7‐chloro‐1‐methyl‐5‐phenyl‐1,3,4,5‐tetrahydro‐3H‐1,4‐benzodiazepine‐2‐one (8a and 8b) as well as 2‐14‐7‐chloro‐4‐carbamoyl‐1‐methyl‐5‐phenyl‐1,3,4,5‐tetrahydro‐3H‐l,4‐benzodiazepine‐2‐one (9) were synthesised from carbobenzoxy‐glycine‐1‐14C. The overall radiochemical yields from carbobenzoxy‐glycine‐1‐14C were 28.9 % (7), 9.5 % (8a and 8b) and 25.3 % (9), respectively. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：377 / 385

页数：9

共 13 条

[1] 1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONES AND THEIR 4-OXIDES
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[4] GREENSTEIN JP, 1961, CHEM AMINO ACIDS, P891
[5] SYNTHESIS OF C-14-LABELED 1,4-BENZODIAZEPINES .2. DIAZEPAM-C-14, DEMETHYLDIAZEPAM-C-14 AND KETAZOLAM-C-14
HSI, RSP
[J]. JOURNAL OF LABELLED COMPOUNDS, 1974, 10 (03): : 389 - 398
[6] KISFALUDY L, 1973, Patent No. 160769
[7] MURRAY A, 1958, ORGANIC SYNTHESES IS, P160
[8] Palosi E, 1973, Acta Pharm Hung, V43, P218
[9] PALOSI E, 1977, GYOGYSZERESZET, V21, P50
[10] PALOSI E, 1976, 4 GYOG K

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