EFFECTS OF 1,8-DIHYDROXYANTHRAQUINONE ON DIFFERENT SEGMENTS OF RABBIT GASTROINTESTINAL TRACT

被引：2

作者：

EICKHOLT, TH

COURVILLE, ND

DANNA, LJ

VERZWYVELT, LJ

WAGUESPACK, GP

机构：

[1] Department of Pharmacology and Toxicology, School of Pharmacy, Northeast Louisiana State College, Monroe, Louisiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 10期

关键词：

1,8‐Dihydroxyanthraquinone effect–gastrointestinal segments; Gastrointestinal segments, rabbit–1,8‐dihydroxyanthraquinone effect; Intestinal contractions–rate; interval; amplitude;

D O I：

10.1002/jps.2600581035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using an isolated muscle bath technique, five different segments of the rabbit gastrointestinal tract (duodenum, jejunum, ileum, ascending and descending colon) were used to record the effects of two doses of 1,8‐dihydroxyanthraquinone (danthron). Transducer‐recorded tracings were made of contractions per minute, interval between contractions, and amplitude of contractions. The results were evaluated and statistical tests among comparisons of the three parameters between the two drug doses and control values indicated the parameter of interval between contractions to be a statistically significant indication of activity. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1289 / +

页数：1

共 17 条

[1] OBSERVATIONS ON USE OF A MOUSE BIOASSAY METHOD FOR INVESTIGATING PURGATIVE ACTIVITY [J].

BRITTAIN, RT ;

GRIMSHAW, JJ ;

DARCY, PF .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1962, 14 (11) :715-&

[2] ACTIVITY OF DIFFERENT SEGMENTS OF RABBIT GASTROINTESTINAL TRACT [J].

EICKHOLT, TH ;

BOX, RH ;

COURVILLE, ND .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (10) :1328-+

[3]

FAIRBAIRN J. W., 1965, PHARM WEEKBLAD, V100, P1493

[4]

FAIRBAIRN JW, 1964, PLANTA MED, V12, P260

[5]

Greiner A C, 1965, Appl Ther, V7, P1096

[6] LAXATIVES .2. RELATIONSHIP BETWEEN STRUCTURE + POTENCY [J].

HUBACHER, MH ;

DOERNBERG, S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (09) :1067-+

[7] LAXATIVES - CHEMICAL STRUCTURE AND POTENCY OF PHTHALEINS AND HYDROXYANTHRAQUINONES [J].

HUBACHER, MH ;

DOERNBERG, S ;

HORNER, A .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION-SCIENTIFIC EDITION, 1953, 42 (01) :23-30

[8] INFLUENCE OF ORAL PERISTALTIC STIMULANT DANTHRON ON PHENOLSULPHONPHTHALEIN EXCRETION TEST [J].

KOSSOVER, MF ;

THREEFOOT, SA ;

BECKHAM, ME .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1964, 247 (06) :694-&

[9] PURGATIVES AND LAXATIVES [J].

MACGREGOR, AG .

BRITISH MEDICAL JOURNAL, 1960, 1 (MAY7) :1422-1424

[10]

MCCABE ES, 1959, PENN MED J, V62, P1662

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