THE EFFECT OF AGING ON THE D1 DOPAMINE-RECEPTORS IN HUMAN FRONTAL-CORTEX

被引：69

作者：

DEKEYSER, J ^{[1
]}

DEBACKER, JP ^{[1
]}

VAUQUELIN, G ^{[1
]}

EBINGER, G ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,PROT CHEM LAB,B-1640 RHODE ST GENESE,BELGIUM

来源：

BRAIN RESEARCH | 1990年 / 528卷 / 02期

关键词：

Aging; Cerebral cortex; Dopamine receptor; D[!sub]1[!/sub; Dopaminergic; Human brain;

D O I：

10.1016/0006-8993(90)91672-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons. © 1990.

引用

页码：308 / 310

页数：3

共 18 条

[1] POSTMORTEM DISTRIBUTION OF DOPAMINE AND HOMOVANILLIC-ACID IN HUMAN-BRAIN, VARIATIONS RELATED TO AGE, AND A REVIEW OF THE LITERATURE [J].

ADOLFSSON, R ;

GOTTFRIES, CG ;

ROOS, BE ;

WINBLAD, B .

JOURNAL OF NEURAL TRANSMISSION, 1979, 45 (02) :81-105

[2]

BROWN RG, 1987, MOVEMENT DISORD, V2, P99

[3]

COTES R, 1989, NEUROSCIENCE, V28, P263

[4]

DEKEYSER J, 1989, J NEUROCHEM, V53, P1096

[5] D1 DOPAMINE-RECEPTORS IN HUMAN PUTAMEN, FRONTAL-CORTEX AND CALF RETINA - DIFFERENCES IN GUANINE-NUCLEOTIDE REGULATION OF AGONIST BINDING AND ADENYLATE-CYCLASE STIMULATION [J].

DEKEYSER, J ;

DIERCKX, R ;

VANDERHEYDEN, P ;

EBINGER, G ;

VAUQUELIN, G .

BRAIN RESEARCH, 1988, 443 (1-2) :77-84

[6] EVIDENCE FOR A WIDESPREAD DOPAMINERGIC INNERVATION OF THE HUMAN CEREBRAL NEOCORTEX [J].

DEKEYSER, J ;

EBINGER, G ;

VAUQUELIN, G .

NEUROSCIENCE LETTERS, 1989, 104 (03) :281-285

[7] REGIONAL AND LAMINAR DENSITY OF THE DOPAMINE INNERVATION IN ADULT-RAT CEREBRAL-CORTEX [J].

DESCARRIES, L ;

LEMAY, B ;

DOUCET, G ;

BERGER, B .

NEUROSCIENCE, 1987, 21 (03) :807-824

[8] CATECHOLAMINE INNERVATION OF THE HUMAN CEREBRAL-CORTEX AS REVEALED BY COMPARATIVE IMMUNOHISTOCHEMISTRY OF TYROSINE-HYDROXYLASE AND DOPAMINE-BETA-HYDROXYLASE [J].

GASPAR, P ;

BERGER, B ;

FEBVRET, A ;

VIGNY, A ;

HENRY, JP .

JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 279 (02) :249-271

[9] IS THE MESOCORTICAL DOPAMINERGIC SYSTEM INVOLVED IN PARKINSON DISEASE [J].

JAVOYAGID, F ;

AGID, Y .

NEUROLOGY, 1980, 30 (12) :1326-1330

[10]

KELLY E, 1986, REV NEUROSCI, V1, P35

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