ANTIBODIES TO PROINSULIN AND INSULIN AS PREDICTIVE MARKERS OF TYPE-1 DIABETES

被引：11

作者：

KUGLIN, B

RJASANOWSKI, I

BERTRAMS, J

GRIES, FA

KOLB, H

MICHAELIS, D

机构：

[1] Diabetes Research Institute, University of Düsseldorf

[2] Central Institute of Diabetes 'Gerhardt Katsch', Karlsburg

[3] Diabetes Education and Therapy Center, Elizabeth Hospital, Essen

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 04期

关键词：

Immunology; Insulin autoantibodies; Islet cell antibodies; Prediction; Proinsulin autoantibodies; Type; 1; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01395.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to test whether proinsulin autoantibodies (IgG‐PAA), insulin autoantibodies (IgG‐IAA), and islet cell antibodies (ICA) may be used to identify subjects at risk for Type 1 diabetes. Pre‐diabetic sera from 18 individuals who later developed diabetes were tested. Results were compared with 18 age‐, sex‐, and HLA‐DR‐matched non‐diabetic control subjects from families with Type 1 diabetes. At a mean of 2.4 yr before the onset of diabetes, ICA were found in 13 patients (vs 0 control subjects, p < 0.001), ELISA‐determined IgG‐IAA in 8 patients (vs 1 control subject, p < 0.05) and ELISA‐determined IgG‐PAA in 4 patients (vs 2 control subjects, NS). ELISA‐determined IgG‐PAA do not appear to be useful predictors of the future development of Type 1 diabetes. 1990 Diabetes UK

引用

页码：310 / 314

页数：5

共 14 条

[1] Eisenbarth GS, Conelly J., Soeldner JS., The ‘natural’ history of Type 1 diabetes, Diabetes Metab Rev, 3, pp. 873-891, (1987)
[2] Kuglin B., Gries FA, Kolb H., Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment, Diabetes, 37, pp. 130-133, (1988)
[3] Kuglin B., Bertrams J., Linke C., Gries FA, Kolb H., Prevalence of cytoplasmic islet cell antibodies and insulin autoantibodies is increased in subjects with genetically defined high risk for insulin‐dependent diabetes mellitus, Klin Wochenschr, 67, pp. 66-73, (1989)
[4] Gleichmann H., Bottazzo GF., Progress towards standardization of cytoplasmic islet cell antibody assay, Diabetes, 36, pp. 578-584, (1987)
[5] Kolb H., Dannehl K., Gruneklee D., Et al., Prospective analysis of islet cell antibodies in children with Type 1 (insulin‐dependent) diabetes, Diabetologia, 31, pp. 189-194, (1988)
[6] Palmer JP., Insulin autoantibodies: Their role in the pathogenesis of IDDM, Diabetes / Metabolism Reviews, 3, pp. 1005-1015, (1987)
[7] Ziegler AG, Ziegler R., Jackson R., Eisenbarth GS., Testing the linear destruction hypothesis in Type 1 diabetes: the Joslin Study, Immunotherapy of Type 1 Diabetes, pp. 155-167, (1989)
[8] MacLaren N., Riley W., Silverstein J., Schatz D., Atkinson M., Progress towards the prediction of insulin‐dependent diabetes: the Gainsville Studies, Immunotherapy of Type 1 Diabetes, pp. 147-154, (1989)
[9] Dean BM, Becker F., McNally JM, Et al., Insulin autoantibodies in the pre‐diabetic period: Correlation with islet cell antibodies and development of diabetes, Diabetologia, 29, pp. 339-342, (1986)
[10] Dean BM, McNally JM, Bonifacio E., Et al., Comparison of insulin autoantibodies in diabetes‐related and healthy populations by precise displacement ELISA, Diabetes, 38, pp. 1275-1281, (1989)

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