LINEAR RECIRCULATION MODEL FOR DRUG DISPOSITION

被引：68

作者：

CUTLER, DJ

机构：

[1] Department of Pharmaceutics, The School of Pharmacy, University of London, London, W.C.1, Brunswick Square

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1979年 / 7卷 / 01期

关键词：

drug disposition; linear systems analysis; mean transit time; recirculation model; single-pass behavior;

D O I：

10.1007/BF01059445

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new approach to the modeling of drug disposition is described. Disposition is regarded as the result of repetitive passes of the drug around the circulation. Mathematical analysis of experimental blood concentration data yields an expression describing the kinetics of a single pass through the tissues. In physicochemical terms the single-pass behavior depends to a large extent on the interaction of the drug with individual tissues, which greatly simplifies interpretation. The method may reveal features of disposition not apparent from experimental blood concentration data. © 1979 Plenum Publishing Corporation.

引用

页码：101 / 116

页数：16

共 11 条

[1] PHARMACOKINETICS OF HEXOBARBITAL IN MAN AFTER INTRAVENOUS-INFUSION [J].