IDENTIFICATION IN HUMAN URINE OF A NATURAL GROWTH INHIBITOR FOR CELLS DERIVED FROM SOLID PEDIATRIC TUMORS

被引：63

作者：

SCHWEIGERER, L

CHRISTELEIT, K

FLEISCHMANN, G

ADLERCREUTZ, H

WAHALA, K

HASE, T

SCHWAB, M

LUDWIG, R

FOTSIS, T

机构：

[1] UNIV HELSINKI,MEILAHTI HOSP,DEPT CLIN CHEM,HELSINKI,FINLAND

[2] UNIV HELSINKI,DEPT CHEM,SF-00100 HELSINKI 10,FINLAND

[3] GERMAN CANC RES CTR,DEPT EXPTL PATHOL CLASS & MOLEC CYTOGENET,W-6900 HEIDELBERG 1,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 22卷 / 04期

关键词：

CANCER; DIET; GENISTEIN; ISOFLAVONES; THERAPY;

D O I：

10.1111/j.1365-2362.1992.tb01460.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Partially purified urine of healthy human subjects contains several fractions able to inhibit the proliferation of cultured human neuroblastoma cells. One of the most active fractions was further analysed by gas chromatography-mass spectrometry and shown to contain genistein, a substance formed in the human body from precursors obtained by diet. Synthetic genistein was able to inhibit the proliferation of human neuroblastoma cells with a half-maximal effect at 5-10-mu-mol l-1 concentrations. Genistein displayed similar potencies in inhibiting the proliferation of cells derived from various other solid pediatric tumours. Our results suggest that genistein is a natural antineoplastic agent present in diet and that it could be useful for the therapy of paediatric tumours.

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页码：260 / 264

页数：5

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