THE SYNTHESIS AND ANTI-HIV ACTIVITY OF PYRIMIDINE DIOXOLANYL NUCLEOSIDES

被引：23

作者：

WILSON, LJ

CHOI, WB

SPURLING, T

LIOTTA, DC

SCHINAZI, RF

CANNON, D

PAINTER, GR

STCLAIR, M

FURMAN, PA

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

[2] EMORY UNIV,SCH MED,VET AFFAIRS MED CTR,DECATUR,GA 30033

[3] BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709

[4] EMORY UNIV,SCH MED,DEPT PEDIAT,DECATUR,GA 30033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80870-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-substituted uracil and cytosine Dioxolanyl nucleosides were synthesized as potential anti-HIV agents. Compounds 3a and 3c were found to be extremely potent in acutely infected human lymphocytes.

引用

页码：169 / 174

页数：6

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