PREPARATION, CHARACTERIZATION AND BINDING-PROPERTIES OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE 3'-RIBOTHIOFORMACETAL PHOSPHATE ANALOG

被引：13

作者：

CAO, XD

MATTEUCCI, MD

机构：

[1] Gilead Sciences, Inc., Foster City, CA 94404

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80852-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A thymine-thymine dimer containing the 3'-ribothioformacetal linkage 2 was prepared and incorporated into an oligodeoxynucleotide(ODN). The positions of 3'-ritothioforacetal 2 linkages were confirmed by partial and complete cleavage using HgCl2. The ODN containing this synthon 2 binds to a complementary single stranded RNA with slightly less affinity as compared to the control ODN containing all 2'-deoxyribose nucleosides and phosphodiester linkages.

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页码：807 / 810

页数：4

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