ADAPTIVE EVOLUTION OF HIGHLY MUTABLE LOCI IN PATHOGENIC BACTERIA

被引：581

作者：

MOXON, ER

RAINEY, PB

NOWAK, MA

LENSKI, RE

机构：

[1] UNIV OXFORD,DEPT PLANT SCI,OXFORD OX1 3RB,ENGLAND

[2] UNIV OXFORD,DEPT ZOOL,OXFORD OX1 3PS,ENGLAND

[3] MICHIGAN STATE UNIV,CTR MICROBIAL ECOL,E LANSING,MI 48824

来源：

CURRENT BIOLOGY | 1994年 / 4卷 / 01期

基金：

英国惠康基金; 美国国家科学基金会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0960-9822(00)00005-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria have specific loci that are highly mutable. We argue that the coexistence within bacterial genomes of such 'contingency' genes with high mutation rates, and 'housekeeping' genes with low mutation rates, is the result of adaptive evolution, and facilitates the efficient exploration of phenotypic solutions to unpredictable aspects of the host environment while minimizing deleterious effects on fitness. © 1994 Elsevier Science Ltd. All rights reserved.

引用

页码：24 / 33

页数：10

共 71 条

[1] AN INVERTIBLE ELEMENT OF DNA CONTROLS PHASE VARIATION OF TYPE-1 FIMBRIAE OF ESCHERICHIA-COLI [J].