CDC2 REGULATORY FACTORS

被引：332

作者：

COLEMAN, TR

DUNPHY, WG

机构：

[1] Howard Hughes Medical Institute, Division of Biology 216-76, California Institute of Technology, Pasadena

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 06期

关键词：

D O I：

10.1016/0955-0674(94)90060-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A growing family of kinases and phosphatases controls the activity of the cyclin-dependent kinase cdc2. The past year has seen the identification of the cdk activating kinase as well as considerable elucidation of the cdc25/wee1 regulatory pathways. Both cdc25 and wee1 appear to be regulated by upstream kinase/phosphatase networks. In addition, it is likely that other regulatory mechanisms cooperate with the wee1/cdc25 phosphorylation systems to control the action of cdc2. Together, these elaborate checks and balances ensure that cdc2 triggers mitosis at the appropriate time.

引用

页码：877 / 882

页数：6

共 39 条

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