SYNTHESIS AND EVALUATION OF 6-ARYLACETAMIDO-2,4-DIAMINOQUINAZOLINES AND RELATED COMPOUNDS AS FOLIC-ACID ANTAGONISTS

被引：14

作者：

HYNES, JB ^{[1
]}

ASHTON, WT ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,COLL PHARM,DEPT PHARM CHEM,CHARLESTON,SC 29401

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1975年 / 18卷 / 03期

关键词：

D O I：

10.1021/jm00237a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：263 / 265

页数：3

共 14 条

[1] QUINAZOLINES AS INHIBITORS OF DIHYDROFOLATE REDUCTASE .1. [J].

ASHTON, WT ;

WALKER, FC ;

HYNES, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :694-697

[2] SYNTHESIS OF 5-SUBSTITUTED QUINAZOLINES AS POTENTIAL ANTIMALARIAL AGENTS [J].

ASHTON, WT ;

HYNES, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1233-1237

[3] ANTIMALARIAL DRUGS .24. FOLATE ANTAGONISTS .2. 2,4-DIAMINO-6-[[ARALKYL AND (HETEROCYCLIC)METHYL]AMINO]QUINAZOLINES, A NOVEL CLASS OF ANTIMETABOLITES OF INTEREST IN DRUG-RESISTANT MALARIA AND CHAGAS-DISEASE [J].

DAVOLL, J ;

DAVIES, HJ ;

CLARKE, J ;

BIRD, OD ;

ELSLAGER, EF ;

JOHNSON, AM .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (08) :812-&

[4] QUINAZOLINE ANALOGUES OF FOLIC ACID [J].

DAVOLL, J ;

JOHNSON, AM .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (08) :997-&

[5] ANTIMALARIAL DRUGS .25. FOLATE ANTAGONISTS .3. 2,4-DIAMINO-6-(HETEROCYCLIC)QUINAZOLINES, A NOVEL CLASS OF ANTIMETABOLITES WITH POTENT ANTIMALARIAL AND ANTIBACTERIAL ACTIVITY [J].

ELSLAGER, EF ;

CLARKE, J ;

DAVOLL, J ;

WERBEL, LM ;

WORTH, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (08) :827-&

[6] FOLATE ANTAGONISTS .5. ANTIMALARIAL AND ANTIBACTERIAL EFFECTS OF 2,4-DIAMINO-6-(ARYLOXY AND ARALKOXY)QUINAZOLINE ANTIMETABOLITES [J].

ELSLAGER, EF ;

WERBEL, LM ;

JOHNSON, J ;

DAVOLL, J ;

CLARKE, J .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1972, 9 (04) :759-&

[7]

ELSLAGER EF, 1974, LECTURES HETEROCYCLI, V2, pS97

[8]

ELSLAGER EF, UNPUBLISHED RESULTS

[9]

ELSLAGER EF, IN PRESS

[10]

FREDGA A, 1953, ARK KEMI, V5, P223

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