SYNTHESES BASED ON 1,2-SECOPENICILLINS .1. OXIDATION

被引：46

作者：

BRAIN, EG ^{[1
]}

EGLINGTON, AJ ^{[1
]}

NAYLER, JHC ^{[1
]}

PEARSON, MJ ^{[1
]}

SOUTHGATE, R ^{[1
]}

机构：

[1] BEECHAM PHARM, RES DIV, BROCKHAM PK, BETCHWORTH RH3 7AJ, SURREY, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1976年 / 04期

关键词：

D O I：

10.1039/p19760000447

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Attempts to introduce oxygenated substituents into the allylic methyl groups of derivatives of (3R,4R)-3-amino-1-(1-carboxy-2-methylprop-1-enyl)-4-mercaptoazetidin-2-one failed. Pb tetra-acetate and certain other oxidants attacked the S atom and the adjacent C atoms, whereas osmium tetraoxide or potassium permanganate removed the complete substituent from the .beta.-lactam N atom.

引用

页码：447 / 451

页数：5

共 15 条

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