PHARMACOKINETICS OF GLYCOPYRRONIUM,I.M.

被引：20

作者：

ALIMELKKILA, TM

KAILA, T

KANTO, J

IISALO, E

机构：

[1] Department of Anaesthesiology, 20520 Turku

[2] Department of Clinical Pharmacology, Turku University Central Hospital, 20520 Turku

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 06期

关键词：

D O I：

10.1093/bja/64.6.667

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A sensitive radioreceptor assay was used to determine the pharmacokinetics of glyco-pyrronium following a single i.m. injection of 8 ug kg-1 in nine surgical patients. Rapid absorption was found, with a mean peak plasma concentration after 16.1 min and mean elimination half-life of 75.4 min. Almost half (49.3%) of the drug was excreted in pharmacologically active form in the urine within 3 h. A significant increase in heart rate (P < 0.05) occurred in 15 min, lasting up to 60 min, and an antisialagogue effect in 10 min, lasting up to 8 h (P < 0.05). There was no measurable glycopyrronium in lumbar cerebrospinal fluid samples (n = 9) taken 40 min after administration of drug. © 1990 British Journal of Anaesthesia.

引用

页码：667 / 669

页数：3

共 6 条

[1] RADIORECEPTOR ASSAY FOR DETERMINATION OF THE ANTIMUSCARINIC DRUG IPRATROPIUM BROMIDE IN MAN [J].