STUDIES ON ALDOSE REDUCTASE INHIBITORS FROM NATURAL-PRODUCTS .3. STUDIES ON ALDOSE REDUCTASE INHIBITORS FROM MEDICINAL PLANT OF SINFITO, POTENTILLA-CANDICANS, AND FURTHER SYNTHESIS OF THEIR RELATED-COMPOUNDS

被引：45

作者：

TERASHIMA, S

SHIMIZU, M

NAKAYAMA, H

ISHIKURA, M

UEDA, Y

IMAI, K

SUZUI, A

MORITA, N

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, SUGITANI, TOYAMA 93001, JAPAN

[2] TOYO PHARMAR CO LTD, INAMI, TOYAMA 93202, JAPAN

[3] DAISO CO LTD, AMAGASAKI, OSAKA 660, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

aldose reductase inhibitor; ellagic acid; ellagic acid derivative; Potentilla candicans; rat lens; Rosaceae; sulfate salt;

D O I：

10.1248/cpb.38.2733

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For several years we have screened natural products having aldose reductase (AR) inhibitory activity. 3,3’,4-Tri-O-methylellagic acid 4’-sulfate potassium salt (2) was isolated from a Mexican herb “Sinfito” (Potentilla candicans) as a potent AR inhibitory active constituent. 2 was more potent (IC5O = 8.0x 10-8m) than ellagic acid, which is one of the natural inhibitors of AR. So we examined the synthesis of ellagic acid derivatives and found that the sulfate group is one of the important function. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2733 / 2736

页数：4

共 19 条

[1] DIMINISHED PROTEINURIA IN DIABETES-MELLITUS BY SORBINIL, AN ALDOSE REDUCTASE INHIBITOR [J].