LUMINOL ENHANCED CHEMILUMINESCENCE OF THE PERFUSED RAT-HEART DURING ISCHEMIA AND REPERFUSION

被引：33

作者：

KUMAR, C ^{[1
]}

OKUDA, M ^{[1
]}

IKAI, I ^{[1
]}

CHANCE, B ^{[1
]}

机构：

[1] UNIV CITY SCI CTR,PHILADELPHIA,PA 19104

来源：

FEBS LETTERS | 1990年 / 272卷 / 1-2期

关键词：

Chemiluminescence; Heart; Ischemia; Luminol; Reperfusion;

D O I：

10.1016/0014-5793(90)80463-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show that the production of Luminol reactive oxygen radicals in the perfused rat heart under ischemia and reperfusion can be monitored continuously by measuring the chemiluminescence of Luminol-perfused hearts. Luminol did not affect the monitored physiological parameters of the hearts. Chemiluminescence increased during ischemia and reperfusion. Superoxide dismutase treatment of the heart before ischemia, but not catalase, abolished these increases. © 1990.

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页码：121 / 124

页数：4

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