MASS-SPECTROMETRIC TECHNIQUES FOR STRUCTURE AND NOVELTY DETERMINATION OF KIRROMYCIN-LIKE ANTIBIOTICS

被引：8

作者：

EDWARDS, DMF ^{[1
]}

SELVA, E ^{[1
]}

STELLA, S ^{[1
]}

ZERILLI, LF ^{[1
]}

GALLO, GG ^{[1
]}

机构：

[1] MERRELL DOW RES INST,LEPETIT RES CTR,VIA R LEPETIT 34,I-21040 GERENZANO,ITALY

来源：

BIOLOGICAL MASS SPECTROMETRY | 1992年 / 21卷 / 01期

关键词：

D O I：

10.1002/bms.1200210110

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Direct liquid introduction negative ion mass spectra have been studied for some kirromycin class antibiotics. A scheme for the interpretation of the mass spectral fragmentation patterns is presented and shown to be useful for structure elucidation and novelty determination. Since these spectra are obtained by liquid chromatography/mass spectrometry, antibiotic isolates need not be highly purified. However, where pure preparations are available confirmation of molecular weight assignments may be obtained with fast atom bombardment ionization.

引用

页码：51 / 59

页数：9

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