LAMOTRIGINE-INDUCED CARBAMAZEPINE TOXICITY - AN INTERACTION WITH CARBAMAZEPINE-10,11-EPOXIDE

被引：102

作者：

WARNER, T

PATSALOS, PN

PREVETT, M

ELYAS, AA

DUNCAN, JS

机构：

[1] UNIV LONDON,INST NEUROL,QUEEN SQ,LONDON WC1N 3BG,ENGLAND

[2] CHALFONT CTR EPILEPSY,EPILEPSY RES GRP,CHALFONT ST PETER,ENGLAND

来源：

EPILEPSY RESEARCH | 1992年 / 11卷 / 02期

关键词：

LAMOTRIGINE; CARBAMAZEPINE; CARBAMAZEPINE-10,11-EPOXIDE; DRUG INTERACTION;

D O I：

10.1016/0920-1211(92)90049-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report an interaction between lamotrigine (LTG), a new antiepileptic drug (AED), and carbamazepine (CBZ) and its primary metabolite CBZ-10,11-epoxide (CBZ-E) in 9 consecutive patients (5 male, 4 female, aged 19-31 years). After introduction of LTG (median daily dose 200 mg, range 100-300 mg) the mean serum CBZ-E concentration increased by 45% (P < 0.01) and the CBZ-E/CBZ ratio increased by 19% (P < 0.02). In 4 patients these changes were associated with clinical toxicity (dizziness, nausea, diplopia). The possibility of an increase in serum CBZ-E concentrations needs to be considered if toxicity symptoms develop when LTG is added to CBZ therapy.

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页码：147 / 150

页数：4

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