LOCALIZATION OF NEUROPEPTIDE-Y AND ATRIAL-NATRIURETIC-PEPTIDE IN THE ENDOTHELIAL-CELLS OF HUMAN UMBILICAL BLOOD-VESSELS

被引:16
作者
CAI, WQ
BODIN, P
SEXTON, A
LOESCH, A
BURNSTOCK, G
机构
[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,GOWER ST,LONDON WC1E 6BT,ENGLAND
[2] UNIV LONDON UNIV COLL,CTR NEUROSCI,LONDON WC1E 6BT,ENGLAND
基金
英国惠康基金;
关键词
NEUROPEPTIDE-Y; ATRIAL NATRIURETIC PEPTIDE; ENDOTHELIAL CELLS; UMBILICAL BLOOD VESSELS; HUMAN;
D O I
10.1007/BF00323584
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The localization of neuropeptide Y (NPY) and atrial natriuretic peptide (ANP) in the endothelial cells of human umbilical blood vessels was studied using the pre-embedding peroxidase-antiperoxidase (PAP) technique for electron microscopy and avidin-biotin-complex (ABC) immunostaining for endothelial cells cultured from umbilical vein. Subpopulations of NPY- and ANP-immunoreactive endothelial cells were present in term umbilical vein and artery. The umbilical vein contained more positive cells than the artery. The percentage of NPY- and ANP-immunoreactive umbilical vein cells in culture was 32% and 44%, respectively, out of a total of 3013 cells examined. The possibility that these potent vasoactive substances located in the endothelial cells of the non-innervated umbilical vessels are involved in the local regulation of blood flow is discussed.
引用
收藏
页码:175 / 181
页数:7
相关论文
共 37 条
[1]  
ALHENCGELAS F, 1982, PROSTAGLANDINS, V24, P137
[2]   SEROTONIN IS LOCALIZED IN ENDOTHELIAL-CELLS OF CORONARY-ARTERIES AND RELEASED DURING HYPOXIA - A POSSIBLE NEW MECHANISM FOR HYPOXIA-INDUCED VASODILATATION OF THE RAT-HEART [J].
BURNSTOCK, G ;
LINCOLN, J ;
FEHER, E ;
HOPWOOD, AM ;
KIRKPATRICK, K ;
MILNER, P ;
RALEVIC, V .
EXPERIENTIA, 1988, 44 (08) :705-707
[3]  
BURNSTOCK G, 1990, J HYPERTENS, V8, pS95
[4]   CHARACTERIZATION AND ACTIONS OF HUMAN UMBILICAL ENDOTHELIUM DERIVED RELAXING FACTOR [J].
CHAUDHURI, G ;
BUGA, GM ;
GOLD, ME ;
WOOD, KS ;
IGNARRO, LJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 102 (02) :331-336
[5]   A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR [J].
CHINKERS, M ;
GARBERS, DL ;
CHANG, MS ;
LOWE, DG ;
CHIN, HM ;
GOEDDEL, DV ;
SCHULZ, S .
NATURE, 1989, 338 (6210) :78-83
[6]   NEUROPEPTIDE-Y MODULATES ADRENERGIC NEUROTRANSMISSION BY AN ENDOTHELIUM DEPENDENT MECHANISM [J].
DALY, RN ;
HIEBLE, JP .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (03) :445-446
[7]   LACK OF INNERVATION OF HUMAN UMBILICAL-CORD - AN IMMUNOHISTOLOGICAL AND HISTOCHEMICAL-STUDY [J].
FOX, SB ;
KHONG, TY .
PLACENTA, 1990, 11 (01) :59-62
[8]   ENDOTHELIN IS A POTENT SECRETAGOGUE FOR ATRIAL NATRIURETIC PEPTIDE IN CULTURED RAT ATRIAL MYOCYTES [J].
FUKUDA, Y ;
HIRATA, Y ;
YOSHIMI, H ;
KOJIMA, T ;
KOBAYASHI, Y ;
YANAGISAWA, M ;
MASAKI, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (01) :167-172
[9]   THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].
FURCHGOTT, RF ;
ZAWADZKI, JV .
NATURE, 1980, 288 (5789) :373-376
[10]   EXPRESSION OF THE ATRIAL NATRIURETIC PEPTIDE GENE IN HUMAN-FETAL HEART [J].
GARDNER, DG ;
HEDGES, BK ;
WU, J ;
LAPOINTE, MC ;
DESCHEPPER, CF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (04) :729-737