ANTIULCER EFFECT OF FLAVONOIDS - ROLE OF ENDOGENOUS PAF

被引：77

作者：

IZZO, AA

DICARLO, G

MASCOLO, N

CAPASSO, F

AUTORE, G

机构：

[1] UNIV NAPLES FEDERICO II,DEPT EXPTL PHARMACOL,I-80131 NAPLES,ITALY

[2] UNIV SALERNO,SCH PHARM,I-84100 SALERNO,ITALY

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 03期

关键词：

PLATELET-ACTIVATING FACTOR; FLAVONOIDS; ETHANOL; ULCER;

D O I：

10.1002/ptr.2650080313

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quercetin, rutin and kaempferol, administered intraperitoneally (25-100 mg/kg) inhibited dose-dependently gastric damage produced by acidified ethanol in rats. Flavone was inactive while naringin was active at higher dose (200 mg/kg). The flavonols tested inhibited dose-dependently the mucosal content of platelet-activating factor (PAF) suggesting that the protective effects of these substances may be mediated by endogenous PAF.

引用

页码：179 / 181

页数：3

共 26 条

[1]

ALCARAZ MJ, 1988, PLANT FLAVONOIDS BIO, V2, P183

[2] MICROCIRCULATORY STASIS PRECEDES TISSUE NECROSIS IN ETHANOL-INDUCED GASTRIC-MUCOSAL INJURY IN THE RAT [J].