DETERMINATION OF MALONALDEHYDE IN HUMAN PLASMA - ELIMINATION OF SPECTRAL INTERFERENCES IN THE 2-THIOBARBITURIC ACID REACTION

被引:20
作者
ESPINOSAMANSILLA, A
SALINAS, F
LEAL, AR
机构
关键词
HUMAN PLASMA; MALONALDEHYDE DETERMINATION; DERIVATIVE SPECTROPHOTOMETRY; 2-THIOBARBITURIC ACID TEST;
D O I
10.1039/an9931800089
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A selective, derivative spectrophotometric method has been developed for the determination of malonaldehyde (MLD), based on a reaction with 2-thiobarbituric acid (TBA). The proposed method has been applied to the determination of MLD in human plasma. A study to eliminate several spectral interferences is described. A comparative study of the results obtained using the proposed derivative method and a conventional TBA method applied to human plasma is presented and the advantages of the proposed method over the conventional method for the determination of MLD in human plasma are evaluated.
引用
收藏
页码:89 / 95
页数:7
相关论文
共 29 条
[1]  
ASAKAWA T, 1980, LIPIDS, V15, P137, DOI 10.1007/BF02540959
[2]   IDENTIFICATION OF ADDUCTS FORMED BY REACTION OF GUANINE NUCLEOSIDES WITH MALONDIALDEHYDE AND STRUCTURALLY RELATED ALDEHYDES [J].
BASU, AK ;
OHARA, SM ;
VALLADIER, P ;
STONE, K ;
MOLS, O ;
MARNETT, LJ .
CHEMICAL RESEARCH IN TOXICOLOGY, 1988, 1 (01) :53-59
[3]   POLAROGRAPHIC METHOD FOR THE DETERMINATION OF PROPANEDIAL (MALONALDEHYDE) [J].
BOND, AM ;
DEPREZ, PP ;
JONES, RD ;
WALLACE, GG .
ANALYTICAL CHEMISTRY, 1980, 52 (13) :2211-2213
[4]  
DRAPER HH, 1986, LIPIDS, V21, P305, DOI 10.1007/BF02536418
[5]   IDENTIFICATION OF N-(2-PROPENAL)ETHANOLAMINE AS A URINARY METABOLITE OF MALONDIALDEHYDE [J].
HADLEY, M ;
DRAPER, HH .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (01) :49-52
[6]   MALONDIALDEHYDE AND THIOBARBITURIC ACID-REACTIVITY AS DIAGNOSTIC INDEXES OF LIPID-PEROXIDATION AND PEROXIDATIVE TISSUE-INJURY [J].
JANERO, DR .
FREE RADICAL BIOLOGY AND MEDICINE, 1990, 9 (06) :515-540
[7]   REACTION OF THIOBARBITURIC ACID WITH SATURATED ALDEHYDES [J].
KOSUGI, H ;
KIKUGAWA, K .
LIPIDS, 1986, 21 (09) :537-542
[8]   FORMATION OF YELLOW, ORANGE, AND RED PIGMENTS IN THE REACTION OF ALK-2-ENALS WITH 2-THIOBARBITURIC ACID [J].
KOSUGI, H ;
KATO, T ;
KIKUGAWA, K .
ANALYTICAL BIOCHEMISTRY, 1987, 165 (02) :456-464
[9]   FORMATION OF RED PIGMENT BY A 2-STEP 2-THIOBARBITURIC ACID REACTION OF ALKA-2,4-DIENALS - POTENTIAL PRODUCTS OF LIPID OXIDATION [J].
KOSUGI, H ;
KATO, T ;
KIKUGAWA, K .
LIPIDS, 1988, 23 (11) :1024-1031
[10]   POTENTIAL THIOBARBITURIC ACID-REACTIVE SUBSTANCES IN PEROXIDIZED LIPIDS [J].
KOSUGI, H ;
KIKUGAWA, K .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 7 (02) :205-207