DOPAMINE INHIBITS TRH-INDUCED MAP KINASE ACTIVATION IN DISPERSED RAT ANTERIOR-PITUITARY-CELLS

被引：22

作者：

OHMICHI, M ^{[1
]}

KOIKE, K ^{[1
]}

NOHARA, A ^{[1
]}

KANDA, Y ^{[1
]}

SAKAMOTO, T ^{[1
]}

ZHANG, ZX ^{[1
]}

HIROTA, K ^{[1
]}

MIYAKE, A ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We recently reported the existence of two separate pathways for thyrotropin releasing hormone (TRW)-induced mitogen-activated protein (MAP) kinase activation in GH3 pituitary tumor cells. To test the role of MAP kinase in TRH action, we examined the effect of dopamine (DA) on TRH-induced MAP kinase in primary cultures of rat anterior pituitary cells. 1 mu M of DA attenuated 1 mu M TRH-induced MAP kinase activity and phosphorylation. 100 ng/ml of islet-activating protein (IAP) blocked these inhibitory effects of DA. These results suggest that crosstalk exists between the DA signaling pathway and the TRH-stimulated MAP kinase activating pathway in rat anterior pituitary cells. (C) 1994 Academic Press, Inc.

引用

页码：642 / 648

页数：7

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