长链非编码RNA多态性与肿瘤相关性的研究

被引：39

作者：

邓齐文

许晔琼

王书奎

机构：

[1] 南京医科大学附属南京医院中心实验室

来源：

医学研究生学报 | 2014年 / 27卷 / 03期

关键词：

长链非编码RNAs; 多态性; 肿瘤;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

长链非编码RNAs(long non-coding RNAs,LncRNAs)是一类转录本长度超过200个核苷酸残基(nt)的RNA分子,位于细胞核或细胞质内,大多由RNA聚合酶Ⅱ转录,但不能编码蛋白质。越来越多的证据表明LncRNA基因也发生遗传变异,导致LncRNA基因存在着广泛的基因多态性,而大多数LncRNA基因多态性与肿瘤的发生、转移和预后相关。文中结合国内外最新报道,对LncRNAs多态性与前列腺癌、肝癌、膀胱癌、急性淋巴细胞性白血病及甲状腺肿瘤的相关性研究进展作一综述,旨在为肿瘤的诊断和治疗提供新的思路。

引用

页码：303 / 306

页数：4

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