不利的子宫内环境增加子代动脉粥样硬化患病风险

被引:3
作者
陆艳
汪俊军
机构
[1] 南京军区南京总医院解放军临床检验医学研究所检验科
关键词
动脉粥样硬化; 表观遗传性状; 妊娠; 危险因素;
D O I
暂无
中图分类号
R543.5 [动脉疾病];
学科分类号
1002 ; 100201 ;
摘要
病理学和流行病学研究表明不利的母体内环境,如母体蛋白质摄入不足、高胆固醇血症、糖尿病(DM)、吸烟等,均可增加子代发生心血管疾病的风险。在子宫内,胎盘和胎儿直接接收来自母体的多种代谢信号:抗氧化剂及促炎、抗炎信息等,并产生特异性应答,致使胚胎DNA甲基化、染色体修饰等过程发生改变,对子代产生持久性的影响,继而导致胎儿成年后动脉粥样硬化(AS)的易感性增强。文中就母体不利因素对子代发生动脉粥样硬化危险性的影响及其相关信号传递和作用机制作一综述。
引用
收藏
页码:984 / 988
页数:5
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