凋亡抑制基因Survivin在胰腺癌中的研究进展

被引:9
作者
徐冬
许利剑
机构
[1] 南京医科大学第二附属医院胆胰外科
关键词
Survivin; 胰腺癌; 凋亡抑制基因;
D O I
暂无
中图分类号
R735.9 [胰腺肿瘤];
学科分类号
摘要
肿瘤的发生不仅与细胞的增殖和异常分化有关,也和细胞凋亡异常有关。Survivin是凋亡抑制蛋白家族(inhibi-tor of apoptosis protein,IAP)的重要成员,它抑制细胞凋亡并在细胞分化中起重要作用。它在分化正常的细胞或组织中较少表达,但在肿瘤中大量表达;该基因可促使肿瘤组织生长,提高肿瘤组织的化疗耐药性并降低患者生存率,阻断其表达可以促进细胞凋亡并抑制肿瘤生长。因此,Survivin已作为肿瘤治疗的一种新靶点而被广泛研究。文中对Survivin在胰腺癌中的研究进展情况作一综述。
引用
收藏
页码:319 / 322
页数:4
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