高迁移率族蛋白B1与心血管疾病相关性的研究进展

被引：4

作者：

刘宇 ^{[1
]}

曹清心 ^{[2
]}

赵仙先 ^{[1
]}

机构：

[1] 第二军医大学长海医院心血管内科

[2] 第二军医大学长海医院中医科

来源：

医学研究生学报 | 2012年 / 25卷 / 01期

关键词：

高迁移率族蛋白B1; 炎性反应; 心血管疾病; 心力衰竭; 心肌缺血-再灌注损伤; 动脉粥样硬化; 心肌梗死;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

摘要：

高迁移率族蛋白B1(high mobility group box1 protein,HMGB1)是一种核蛋白质,其可由坏死细胞以及活化的免疫细胞释放至细胞外而具有细胞因子的活性,继之启动免疫反应和引发炎性反应。近年来,大量研究证实HMGB1与心力衰竭(heart failure,HF)、心肌缺血-再灌注(ischemia/reperfusion,I/R)损伤、动脉粥样硬化(atherosclerosis,AS)、心肌梗死(myo-cardial infarction,MI)等疾病有密切关系,通过研究HMGB1在心血管疾病发生发展过程中的机制,可为心血管疾病的临床治疗找到新靶点。

引用

页码：99 / 102

页数：4

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